Anjin cholesterol drug Repatha significantly reduces heart attack
Heavy! Amgen cholesterol drug Repatha significantly reduces heart attack and stroke risk in Phase 3 clinical trials
March 24, 2017 - A Phase 3 clinical trial showed that Remase, a cholesterol drug, lowers LDL-C levels and reduces cardiovascular risk.
This clinical trial showed that Repatha minimizes LDL-C levels and helps reduce the risk of major cardiovascular events such as heart disease, stroke and coronary revascularization.
Repatha is a human monoclonal antibody that inhibits the proprotein convertase subtilisin 9 (PCSK9).
The study focused on the primary adverse cardiovascular event (MACE) composite endpoint for first heart, stroke, or cardiovascular deaths.
The results of the trial showed that the addition of Repatha to enhance statin therapy significantly reduced the risk of these events by 20%.
When used with statins, Repatha reduced the median concentration of LDL-C from 92 to 30 mg/dL, and by 59% at 48 weeks, maintaining this level throughout the trial.
Amgen scientists developed Repatha by studying the interaction of PCSK9 with the LDL receptor (LDLR), including the binding site of LDLR and PCSK9, and the antibodies they developed could bind to this site, thereby blocking the interaction between PCSK9 and LDLR.
According to the company, the primary endpoint of this clinical trial was the time to cardiovascular death, myocardial infarction, stroke, hospitalization for unstable angina, or coronary revascularization. The secondary endpoints were cardiovascular death, myocardial infarction, and stroke.
Sean Harper, executive vice president of research and development at Amgen, said: "This is important for high-risk patients. Because these patients have used the best therapy before, they still face a higher risk of extra cardiac events. It’s only two years since these patients used Repatha, so it’s very compelling to have such a large reduction in the risk of cardiovascular events in these patients.â€
Shanghai Chuangsai Technology has excellent performance, interleukin cytokines, fetal bovine serum, electrophoresis equipment scientific instruments, raw material drug standards, chemical reagents, cell culture consumables, Shanghai Chuangsai, mass products special promotions, welcome to inquire!
The function of ladder string are used in aluminum with screens,PVC and wood curtain,also,we can manufacture these according to your orders.
Ladder String
WUXI MIFUN INTERNATIONAL TRADE CO.,LTD , https://www.mifunblind.com