Anti-infective flu vaccine
New animal model studies may open the door to a flu vaccine that is resistant to a wide range of strains, so people can use it every year. Chih-Jen Wei and colleagues report that DNA from the flu virus is used to stimulate the immune system (before using a seasonal flu vaccine to boost the immune system) in mice, ferrets and non-human primates. Antibodies are produced in animals that neutralize a wide range of H1N1 viruses. Currently, seasonal influenza vaccines induce the production of antibodies targeting the viral hemagglutinin (HA) protein, but this protein rapidly mutates, making the virus resistant to the vaccine.
Some regions of the HA protein are more stable, so researchers are more willing to design a vaccine that induces antibodies that target these regions, and in turn protects the body against a wide range of strains. Wei and colleagues now show that a “pre-stimulation-enhancement†combination vaccine provides protection to the body in animal models.
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The "pre-stimulation primer" is composed of DNA encoding influenza HA, and the "enhancer" is a conventional seasonal influenza vaccine. This combination vaccine neutralizes viruses from mouse, ferrets and non-human primate serum samples, and protects their bodies from mice and ferrets without being affected by a different influenza strain. infection. Further research is needed to determine how ideal this vaccine strategy or similar vaccine strategy will be in humans.
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