Peking University makes important progress in the field of glycochemical biology
As one of the biological macromolecules, glycans not only participate in important life processes such as regulating development, signal transduction, and immune recognition, but also play an important role in the occurrence and development of diseases. Compared with nucleic acids and proteins, glycans have the characteristics of complex structure and diverse forms, so their functional analysis is very challenging. Chen Xing's group at the School of Chemistry, Peking University is committed to developing chemical labeling strategies and imaging methods to reveal the biological function and molecular mechanism of glycosylation at the level of living cells and living bodies. On the one hand, they developed new non-natural sugar molecular probes to study the interaction between sugar and protein (J. Am. Chem. Soc. 2013, 135, 9244); at the same time, they developed a cell-selective polymer Sugar labeling technology, combined with biological orthogonal reaction, enables targeted labeling, fluorescence imaging and enrichment identification of glycans on the surface of cancer cells (J. Am. Chem. Soc. 2012, 134, 9914). On the other hand, they focus on the development of new imaging modes, based on the concept of "biological orthogonal Raman labeling", combined with Raman imaging technology, to achieve direct labeling and imaging of glycans without the use of biological orthogonal reactions (Angew. . Int. Ed. 2013, 52, 7266). The Raman detection method of glycans is expected to be complementary to fluorescence technology and used to study a series of different glycosylation processes.
Based on the foundation of previous work, Chen Xing's group has recently achieved new breakthroughs in protein-specific sugar chain labeling and imaging. Existing labeling methods can only label all sugar chains at the same time, and cannot specifically label sugar chains on a specific protein. This technical bottleneck prevents people from accurately and deeply studying how specific proteins are regulated by glycosylation. The research group developed a chemical double labeling method to achieve protein-specific sugar chain labeling and imaging, providing a new way to solve a long-standing problem in the field of sugar biology (J. Am. Chem. Soc . DOI: 10.1021 / ja410086d). The Journal of the American Chemical Society introduced the work in the form of Spotlight (DOI: 10.1021 / ja5001483). The American Chemical Society "Chemical & Engineering News" (2014, Jan 6, page 10) reported this work in the form of News of the Week. This work was also highly praised by ACS Press, and was rated as the first selected paper of ACS Editors' Choice, which reflects the high-level research results from China (“Our reviewers and editors praised Dr Chen's superb work, calling it an important landmark in glycobiology. We are pleased to be able to honor Dr Chen's article in this way, which in turn reflects the superb quality of research coming from China. ").
This series of work was supported by the National Natural Science Foundation of China
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