Elucidation of drug-resistant atypical mycobacteria infection among patients
In the United States and Europe, approximately 3% to 10% of patients with vesicular fibrosis are suffering from atypical cystobacteria of drug-resistant cysts, and this number is still on the rise. Infection is easy to damage the lungs of the human body, and treatment is quite tricky.
The genetic correlation of the genomes of 31 patients infected with cystic atypical mycobacteria was compared using genomic sequence and antimicrobial susceptibility testing. Of course, these patients were isolated. The subjects of this group were due to pulmonary infection. Patient admitted to Cambridge Piper Hospital for treatment.
The researchers also used a social network analysis method to compare patients with genetic genetic clusters and patients without genetic clusters, and compared the probability of cross-infection between the two. Source of infection, such as bronchoscopy, drinking water, etc.
The study found that patients with two types of genetic clusters were more susceptible to infection. This was due to the fact that they were infected with atypical amylin, a subspecies massiliense (obtained from 11 patients) that was genetically highly similar or nearly Similar. The difference in DNA base pairs is less than ten pairs.
Compared with other patients, 11 patients who were isolated separately showed a closer relationship, which further aggravated the infection between them.
This group of patients also has a higher chance of being infected by diseases spread inside the hospital.
The team further conducted a series of experiments to confirm their proposed cross-infection theory. They proposed that the abscess atypical mycobacterial subspecies massiliense can produce mutations in the process of infecting another patient from one patient, and can spread the mutation from a few The bacteria isolated from amikacin and clarithromycin have the same characteristics in one patient (these patients have not used antibiotics for a long time).
The development of whole-genome sequencing has made us clearly aware that patients can spread the germs to each other, and to some extent can see the whereabouts of the spread, a task that was previously impossible.
Although the evidence for the spread of atypical mycobacterial subspecies massiliense in patients is conclusive, the exact mechanism of cross-infection has not yet been established. Thanks to the current strict policy of controlling infection, I believe that all of the pathogens are transmitted through indirect In the process of infection, for example through contaminants (hair, clothing, bed sheets, etc.) or through aerosols (used during lung function tests) to produce infection during the process.
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