University of Tokyo, Japan announces new results of joint research with Shimadzu

A few days ago, the Institute of Medical Sciences of the University of Tokyo, Japan, announced the results of a joint research with Senior Researcher Tanaka Kenji of Shimadzu Corporation (guest professor at the University of Tokyo), etc. "Successfully clarified glycosylation modification of cancer cell trace proteins based on new mass spectrometry" . This achievement is expected to promote the development of new disease markers.

The publishers of this research result are:

Zhou Weizhuo (special researcher in the field of tumor cell sociology, Institute of Medical Sciences, University of Tokyo)

Kiyuki Kiyuki (Professor of Tumor Cell Sociology, Institute of Medical Sciences, University of Tokyo)

Kenichi Tanaka (Visiting Professor, Institute of Medical Sciences, University of Tokyo, Senior Researcher, Shimadzu Corporation / Director, Shimadzu Tanakaichi Memorial Quality Analysis Institute)

This study established a mass spectrometry method that can easily analyze sugar chains attached to trace proteins from cancer cells and the like. Its innovation lies in the establishment of a mass spectrometry technology that can separate and measure sugar chain additional protein fragments (glycopeptides) and unmodified peptides in one step, and is applied to the analysis of cancer cell membrane proteins. This study shows for the first time in the world the existence of non-uniformity of glycosylation modification that cannot be detected by traditional methods, as well as the unpredictable presence of additional sites of sugar chains. Since the glycosylation modification of proteins present on the surface of cancer cells can be accurately analyzed, new cancer markers are expected to be discovered. This analysis method will also be a very effective means for the quality control of biopharmaceutical products.

The research results are published in the magazine "PLoS ONE" (published online for free).

Public URL: http://dx.plos.org/10.1371/journal.pone.0043751

Public time: August 23, 2012,

Thesis title: Detection of the Heterogeneous O-Glycosylation Profile of MT1-MMP Expressed in Cancer Cells by a Simple MALDI-MS Method

DOI number: 10.1371 / journal.pone.0043751

Authors: Takuya Shuo, Naohiko Koshikawa, Daisuke Hoshino, Tomoko Minegishi, Hiroko Ao-Kondo, Masaaki Oyama, Sadanori Sekiya, Shinichi Iwamoto, Koichi Tanaka, Motoharu Seiki

About Shimadzu

Shimadzu Enterprise Management (China) Co., Ltd. is a local legal person company established in China in 1999 by Shimadzu Corporation to expand the scale of its business in China.

At present, Shimadzu Enterprise Management (China) Co., Ltd. has 13 branches throughout China, and its business scale is continuously expanding. There are analysis centers in Beijing, Shanghai, Guangzhou, Shenyang, and Chengdu; a network of sales agents covering 30 provinces across the country; and more than 60 technical service stations to build a complete system that provides good services to users.

As a global production base, Shimadzu has built a product production and supply system not only for Chinese customers, but also for the world, and strives to build a product production system that meets the requirements of the Chinese market. With the goal of "for the health of mankind and the earth", Shimadzu will always strive to provide users with more advanced products and more satisfactory services.

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