Shenzhen Advanced Institute made breakthrough progress in nanoprobe technology research
The Nanomedicine Research Group led by Researcher Cai Lintao of the Institute of Biomedicine and Technology (Preparation), Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences has recently made breakthrough progress in nanoprobe technology research.
Quantum dots, also known as nanocrystals, have a particle size generally between 1 and 10 nm, with long fluorescence lifetime, high photochemical stability, wide excitation spectrum, narrow emission spectrum, and precisely tuned emission The excellent characteristics such as wavelength have important application prospects in the basic research of nanobiomedicine and life sciences. It can achieve ultra-trace detection of target molecules and multi-color labeling. , Playing an increasingly important role in molecular detection, cell labeling and in vivo imaging.
Surface modification of fluorescent quantum dots is an important step in its application to biological tracer analysis and cell imaging. Cai Lintao's group designed and synthesized a new type of multifunctional polymer for quantum dot modification. On this basis, "Click Chemistry" was introduced to develop a universal method based on quantum dots for live virus labeling The method provides a powerful help to further reveal the mechanism of virus infection in host cells and the prevention, control and treatment of related diseases at the subcellular level of cells. Mechanism and its early diagnosis and treatment, etc.) laid a good foundation.
Related achievements were published in the newly published "Journal of the American Chemical Society" (J. Am. Chem. Soc.).
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